MyBioSource.com's JNK Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Flow Cytometry, Immunofluorescence, Immunoprecipitation, and Western Blot. The JNK Antibody was generated using MAPK8 as the antigen and it reacts with Human, Mouse, and Rat.
Description
c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1alpha1, JNK1beta 1, JNK2alpha1, JNK2beta 1 and JNK3alpha1, which represent the p46 isoforms, and JNK1alpha2, JNK1beta 2, JNK2alpha2, JNK2beta 2 and JNK3beta 2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and transformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38